Some Pathophysiologic Changes in Experimental Intrauterine Malnutrition
نویسنده
چکیده
The two major causes (48) of intrauterine human growth retardation (IUGR) (63), which has become a major concern to neonatalogists (3,4), are a reduction in the blood flow to the fetus and maternal malnutrition. The physiological and biological changes observed in both human and animal species include a delay or arrest in cell multiplication, which may spare some organs while affecting others. Experimentation on intrauterine retarded growth has been conducted on rats (48,67), guinea pigs (46), lambs, monkeys, and pigs; IUGR has been induced either by maternal proteinocaloric deprivation or by vascular ligature or microemboli caused by plastic microspheres during gestation (Fig. 1). The following consequences have been observed in the animal and occasionally also in the human being (48):
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